Aminated poly(L-histidine) as new pH-sensitive DNA carrier
نویسندگان
چکیده
منابع مشابه
A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
Class II MHC molecules undergo conformational changes on shifts of the pH. As a consequence, low-affinity peptides tightly bound at pH 7.0 can be released at pH 5.0. The imidazole group of histidine is the only amino acid side chain affected within this range. At pH 5.0 the group is positively charged, polar, and hydrophilic, whereas at pH 7.4 it is neutral, apolar, and hydrophobic. In this stu...
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: Methylated poly(l-histidine) (PLH-Me), our original polypeptide, has controlled the contents of dimethylimidazolium, τ/π-methylimidazole and imidazole groups for efficient gene delivery. The screening for the PLH-Me as DNA carrier has been carried out by use of the PLH with 25 mol% (τ-methyl, 16 mol%; π-methyl, 17 mol%; deprotonated imidazole, 41 mol%), 68 mol% (τ-methyl, 16 mol%; π-methyl, 8...
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ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2004
ISSN: 0261-3166
DOI: 10.1093/nass/48.1.229